Use of virtual gene panels

Panels used for whole genome sequencing indications in the GMS will be denoted by the panel type field 'GMS Rare Disease Virtual'. Other GMS test types have the panel type ‘GMS Rare Disease’. For the GMS, consensus gene panels are finalised through a review process with a disease specialist test group and only signed-off panels are used for analysis. Signed-off panels and associated versions are available in PanelApp. We encourage NHS GLH members to continue to contribute their expertise by reviewing genes on panels, adding new genes or evidence over time, which will then be assessed for periodic updates.