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Pipeline sensitivity and precision

Variant Type Measure Sensitivity Precision Truth set
Single Nucleotide Variants Mean 0.9971 0.9989 HG002 (Child, Ashkenazi Jewish Trio) sample with Genome in a Bottle truth set (high confidence regions) - variant detection performed as a singleton
Single Nucleotide Variants 95% credible interval 0.9971-0.9972 0.9989-0.9989 HG002 (Child, Ashkenazi Jewish Trio) sample with Genome in a Bottle truth set (high confidence regions) - variant detection performed as a singleton
Indels Mean 0.9912 0.9956 HG002 (Child, Ashkenazi Jewish Trio) sample with Genome in a Bottle truth set (high confidence regions) - variant detection performed as a singleton
Indels 95% credible interval 0.9911-0.9914 0.9955-0.9957 HG002 (Child, Ashkenazi Jewish Trio) sample with Genome in a Bottle truth set (high confidence regions) - variant detection performed as a singleton
Copy Number Variants (>2Kb) Mean 0.9779 N/A Clinically significant CNVs detected by standard of care tests in accredited labratories
Copy Number Variants (>2Kb) 95% credible interval 0.9609-0.9929 N/A Clinically significant CNVs detected by standard of care tests in accredited laboratories
Short Tandem Repeat Expansions Mean 0.9828 0.9194 STR expansion tests (positive and negative) at target loci performed in accredited laboratories
Short Tandem Repeat Expansions 95% credible interval 0.9343-1 0.8252-0.9943 STR expansion tests (positive and negative) at target loci performed in accredited laboratories